In this one-day seminar we will be introduced to the theoretical and clinical work of two ground-breaking analytical psychologists and authors, Dr Jean Knox and Margaret Wilkinson, who have both embraced developmental neuroscience to deepen their understanding of the way the human mind functions. They will discuss how new neuroscientific paradigms have led them to greater knowledge and confidence about why certain psychotherapeutic interventions are effective. They will offer an emergent model of human development that places environmental and cultural influence, especially the earliest relationships with caregivers, right at the heart of human psychological and emotional development. In the seminar we will explore how neuroscience can help us to develop and update our clinical theories by offering more accurate models to explain the clinical phenomena we work with, particularly those linked to a history of early relational trauma. The discussion will be set in the context of clinical discussion of case material and an examination of transference and countertransference dynamics. The day will conclude with a live supervision.